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相关概念视频

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

9.7K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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相关实验视频

Updated: Jun 3, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

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单细胞转录组数据中的决定性模式

Zhixing Cao1,2, Yiling Wang3, Ramon Grima4

  • 1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. z.cao@queensu.ca.

NPJ systems biology and applications
|January 11, 2025
PubMed
概括
此摘要是机器生成的。

单细胞转录组数据中的决定性模式来自有限的样本大小效应,而不是人工制造物或生物学. 我们的理论准确地预测了这些模式在各种单细胞测量平台.

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科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 生物物理学的生物物理.

背景情况:

  • 单细胞转录组数据分析经常揭示出意想不到的模式.
  • 区分真正的生物信号与技术工件对于准确的解释至关重要.

研究的目的:

  • 为了确定在单细胞转录组数据中观察到的确定性模式的起源.
  • 开发一个理论框架来解释这些模式.
  • 通过各种单细胞测量技术验证理论.

主要方法:

  • 对单细胞转录组数据集的统计分析.
  • 基于有限样本大小效应的理论模型的开发.
  • 验证使用来自多重错误强的光现场混合 (MERFISH) 和五个测序平台的数据.

主要成果:

  • 确定性模式在单细胞转录组数据的统计图中得到证实.
  • 一个新的理论将这些模式归因于有限的样本大小效应.
  • 该理论准确地预测了MERFISH和各种测序数据中观察到的模式.

结论:

  • 观察到的确定性模式是转录学学中有限采样的一个固有的新兴性质.
  • 这些模式并不表明测量工件或特定的生物机制.
  • 开发的理论为理解跨多个单细胞技术的数据特征提供了一个强大的框架.