在发育过程中暴露在 perfluorooctane sulfonate (PFOS) 中会损害子宫内膜受体
Rui Ren1,2,3, Xinyue Zhou1, Tianyu Jia1,2
1The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Scientific reports
|January 11, 2025
概括
暴露在 perfluorooctane sulfonate (PFOS) 中会损害子宫内膜细胞并损害生殖健康. 这种化学物质破坏了线粒体功能,减少了关键蛋白质,并影响了子宫的受容性,可能导致胚胎植入失败.
科学领域:
- 环境科学 环境科学
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- perfluorooctane sulfonate (PFOS) 是一种持久性环境污染物,具有已知的健康风险.
- 新出现的证据将PFOS暴露与各种疾病联系在一起,需要对其对人类生殖健康的具体影响进行调查.
研究的目的:
- 研究PFOS暴露对子宫内膜受体性和人类子宫内膜 stromal 细胞 (hESCs) 的影响.
- 阐明PFOS影响子宫内膜耐受性和细胞功能的机制.
主要方法:
- 在体外研究中使用hESC来评估细胞活性,细胞亡,线粒体损伤和蛋白质表达 (HOXA10,ITGB3,FOXO1).
- 在体内动物模型 (小鼠) 评估子宫形态,皮诺波德,雌性周期和PFOS暴露后的整体子宫内膜受体性.
主要成果:
- PFOS显著降低了子宫内膜介质细胞活性,并以剂量依赖的方式促进了细胞亡.
- 观察到线粒体损伤,以及HOXA10和ITGB3的表达减少,FOXO1表达增加.
- 动物研究显示了子宫形态的改变,受损的脚,受损的雌性周期和受损的子宫内膜受容性.
结论:
- 活体内PFOS积累对子宫内膜细胞活力和功能产生负面影响.
- 通过破坏线粒体功能和降低子宫内膜受体性,PFOS可能会导致胚胎植入失败.
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