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Updated: Jun 3, 2025

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
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人工强制展开的蛋白质反应减少了多个临床前模型的ALS/FTD的疾病特征

Vicente Valenzuela1, Daniela Becerra1, José I Astorga1

  • 1Program of Cellular and Molecular Biology, Biomedical Sciences Institute (ICBM), Universidad de Chile, Santiago, Chile; Biomedical Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.

Molecular therapy : the journal of the American Society of Gene Therapy
|January 12, 2025
PubMed
概括

通过XBP1s增强未折叠的蛋白质反应 (UPR) 来恢复内质网膜 (ER) 蛋白质稳定性,对治疗肌缩侧面硬化症 (ALS) 和前性痴呆症 (FTD) 显示出有前途. 这种方法在疾病模型中改善了运动功能和生存率.

关键词:
压力ERER压力ERER压力在XBP1中使用.骨髓缩侧面硬化症 (ALS) 是一种前性痴呆症前性痴呆症基因治疗的基因疗法蛋白质聚合蛋白质的聚合物不折叠的蛋白质反应反应

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