老年人中萨科佩尼亚阶段角度的诊断性能:系统性审查和诊断元分析
Shuanglong Hou1, Xin Zhao2, Jiaxin Wei1
1Department of Sport Rehabilitation, Xi'an Physical Education University, Xi'an, Shaanxi 710068, China.
Archives of gerontology and geriatrics
|January 12, 2025
概括
阶段角显示在诊断肉类的准确度中等,最佳切断范围为4.20-4.50°. 需要进一步的大规模研究来确认其用于诊断肉类症的临床用途.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 生物医学工程 生物医学工程
背景情况:
- 对老年人的健康来说,诊断肉症至关重要.
- 阶段角是肉症的潜在生物标志物.
- 现有证据证明相角对萨尔科佩尼亚的诊断准确性需要合成.
研究的目的:
- 系统地审查和元分析萨尔科佩尼亚阶段角度的诊断性能.
- 为了确定相角的聚合灵敏度,特异性和AUC,用于诊断肉类症.
- 探索影响相角诊断精度的因素.
主要方法:
- 在PubMed,Web of Science,Embase和Scopus数据库中进行系统搜索.
- 使用QUADAS-2进行的包含研究的质量评估.
- 对元分析的双变随机效应模型,包括元回归和子组分析.
主要成果:
- 纳入了15项研究,共有4063名参与者;总体偏差风险很高.
- 聚合灵敏度为0.74 (95% CI:0.71-0.78) 和聚合特异性为0.75 (95% CI:0.70-0.79).
- 曲线下的面积 (AUC) 为0.79 (95% CI:0.76-0.83);在4.20-4.50°切线上观察到的最佳性能.
结论:
- 阶段角度显示了萨尔科佩尼亚的中等诊断性能.
- 在诊断肉症时,相角的最佳切断间隔可能是4.20-4.50°.
- 建议进行高质量的,大规模的多中心前性研究,以验证临床适用性.
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