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寻找白蛋白的NIR染料用于高灵敏度成像膜过屏障的分解

Lang Bai¹, Yunlong Jia², Shengjie Ma³

¹Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, 130021, PR China; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun, 130012, PR China.

|January 12, 2025

概括

研究人员开发了新的近红外II (NIR-II) 染料,用于针对白蛋白进行非侵入性功能成像. 这允许实时检测蛋白尿和微专尿,彻底改变了病诊断.

科学领域:

生物医学成像技术生物医学成像技术
腎臟病學 (nephrology) 是一種醫學專業.
诊断工具诊断工具

背景情况:

功能障碍可能导致严重的疾病,影响代谢平衡.
淋巴膜过屏障 (Glomerular Filtration Barrier,GFB) 的破坏导致蛋白尿和功能衰竭,需要有效的监测.
目前用于GFB完整性评估的方法缺乏非侵入性成像对比剂.

研究的目的:

开发一种新的成像方法,用于实时,非侵入性地评估GFB完整性.
为了创建近红外II (NIR-II) 光染料,具有固有的白蛋白向能力.
为了能够早期检测和定量测量蛋白尿和微专尿.

主要方法:

开发用于NIR-II成像的寻找白蛋白的氨酸染料.
在小鼠模型中内源性白蛋白的高分辨率体内成像.
染料的应用,以实时检测和量化患者的白色素尿.

主要成果:

通过使用NIR-II染料,成功地以高分辨率成像了内源性白蛋白.
在小鼠模型中检测到甚至轻微的GFB干扰和微量蛋白尿.
能够在没有尿液收集的情况下实时确定白色素尿和准确量化测量微白色素尿.

结论:

寻找白蛋白的NIR-II染料为GFB完整性的敏感,体内成像提供了一种革命性的方法.
这项技术有助于快速诊断微蛋白尿症和各种脏相关疾病.
开发的染料具有改变病学临床应用的巨大潜力.

关键词:

寻找白蛋白的氨酸染料.接近红外II成像技术非侵入性淋巴膜过屏障成像技术对微专尿的定量测量.

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