在使用机器学习算法预测心脏代谢健康结果时整合遗传学,代谢物和临床特征 - - 一个系统性审查
Xianyu Zhu1, Eduard F Ventura2, Sakshi Bansal1
1Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences and Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, RG6 6DZ, UK.
Computers in biology and medicine
|January 12, 2025
概括
将临床,代谢物和遗传数据与机器学习 (ML) 集成,可以改善心脏代谢健康 (CMH) 的预测,特别是2型糖尿病 (T2D) 和血压 (BP). 需要进行进一步的研究,以优化CMH中生物标志物选择的ML方法.
科学领域:
- 心血管和代谢健康研究研究
- 生物医学数据科学 生物医学数据科学
- 医疗保健中的机器学习
背景情况:
- 使用机器学习 (ML) 整合临床,代谢物和遗传数据的心脏代谢健康 (CMH) 预测产生了可变的结果.
- 现有的模型经常使用单个或配对的数据类型,需要评估多模式方法.
研究的目的:
- 评估多模式ML方法是否与单一或配对模式模型相比,改善CMH结果预测.
- 为了比较当前基于ML的CMH预测模型中使用的方法.
主要方法:
- 对五个数据库 (1998-2024) 的系统文献搜索,用于使用多模数据进行CMH结果的ML预测建模研究.
- 偏差风险评估和研究特征的叙事综合,ML算法,数据预处理和评估指标.
主要成果:
- 多种模式的方法始终提高了对2型糖尿病 (T2D) 和血压 (BP) 的预测,而不是单一或配对模式.
- 基因数据显示,在三项研究中,预测性表现最低.
- 方法的异质性,包括缺少的数据和多样化的特征选择,特征重要性有限的全面比较.
结论:
- 使用多模式方法的ML算法显示了改善T2D和BP预测的前景.
- 通过各种ML算法和优化方法的进一步研究对于在CMH预测中推进生物标志物选择至关重要.
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