孕产妇的饮食和成年人对认知障碍的脆弱性:可能与阿尔茨海默病有关吗?
Laetitia Merle1, Marialetizia Rastelli2, Frédérique Datiche1
1Centre des Sciences du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, Dijon, France.
Neuroendocrinology
|January 12, 2025
概括
母亲过度营养可能会损害后代的认知功能,增加阿尔茨海默病 (AD) 的风险. 本综述探讨了母亲的饮食,后代的神经发育和AD病理之间的联系,强调了肠道微生物群的作用.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 衰老是认知衰退和神经退行性疾病的主要危险因素.
- 环境因素,特别是营养,显著影响认知健康.
- 母亲的营养复杂地影响后代的饮食行为,新陈代谢和认知能力.
研究的目的:
- 审查证据,将母亲的过度营养与后代的认知障碍联系起来.
- 探索母亲的饮食和阿尔茨海默病 (AD) 病理学的关系.
- 找出可能调解这些效应的机制.
主要方法:
- 人类和动物模型研究的文献综述.
- 对与认知障碍和AD相关的细胞和分子标志的分析.
- 研究涉及代谢疾病和肠道微生物群的间接机制.
主要成果:
- 研究表明,不平衡的母亲饮食和后代的认知缺陷之间存在相关性.
- 发现的潜在的AD特征包括突触功能障碍,神经发生变化,神经炎症,氧化应激和蛋白质聚合.
- 母亲的饮食可能会通过代谢障碍和肠道失调促进后代对神经退行的脆弱性.
结论:
- 孕产妇过度营养会使后代面临认知障碍和神经退行症的风险.
- 代谢性疾病和肠道微生物群的改变被认为是介导因素.
- 进一步的研究对于个性化营养和药物来解决认知衰退至关重要.
相关概念视频
Alzheimer's Disease: Overview
440
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
440
Psychoneuroimmunology: Diabetes and Cancer
22
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
22
Cognitive Development During Adulthood
49
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
49
Dementia
94
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
94


