用于抗瘤治疗的基于铜的生物材料:最近的进展和前景
1The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education of Xiangya Hospital and School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China; Hunan Key Laboratory of Non-Resolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Acta biomaterialia
|January 12, 2025
概括
基于铜的生物材料在癌症治疗中表现有前途,通过提供药物并诱导癌症细胞死亡. 本综述探讨了它们的抗瘤功能,机制和设计策略,以推进临床应用.
科学领域:
- 生物材料科学 生物材料科学
- 在瘤学瘤学.
- 纳米技术 纳米技术
背景情况:
- 铜是一种必不可少的微量元素,在生物系统中起着重要作用.
- 基于铜的生物材料为癌症治疗提供生物相容性和多种功能.
- 这些材料正在研究用于治疗各种恶性瘤,包括瘤和癌症.
研究的目的:
- 提供铜基生物材料的抗瘤功能和机制的概述.
- 讨论开发用于癌症治疗的新型多功能铜基纳米材料的设计策略.
- 突出这些材料的优点和局限性,加快其临床应用.
主要方法:
- 对癌症治疗中基于铜的生物材料现有研究的文献综述.
- 治疗机制的分析,包括药物输送和诱导细胞死亡 (ferroptosis,cuproptosis,apoptosis,pyroptosis).
- 检查瘤成像和免疫激活的先进设计方法.
主要成果:
- 基于铜的生物材料作为治疗剂的载体,使得精确的输送和受控的释放.
- 它们可以通过各种细胞死亡途径抑制癌细胞的增殖和入侵.
- 这些材料还支持瘤成像和免疫激活,增强治疗结果.
结论:
- 基于铜的生物材料为创新的癌症治疗提供了一个有前途的平台.
- 需要进一步的研究来充分阐明它们的功能能力和优化它们的设计.
- 加快这些多功能纳米材料的临床应用对于推进瘤治疗至关重要.
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