来自印度东部的Mycobacterium结核病菌株的基因型和表型多样性
Arup Ghosh1, Viplov Kumar Biswas1, Himadri Bhusan Bal2
1Immunogenomics & Systems Biology group, Institute of Life Sciences (ILS), Bhubaneswar, Odisha, India; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Bhubaneswar, Odisha, India.
概括
基因组测序揭示了印度独特的Mycobacterium结核病血统和高耐药性.
科学领域:
- 基因组学就是基因组学.
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 对于印度东部的Mycobacterium结核病 (M.结核病) 存在有限的基因组数据.
- 了解区域多样性和耐药性对于有效控制结核病至关重要.
研究的目的:
- 调查印度东部M.结核病的基因组多样性和耐药性模式.
- 分析来自印度东北部,奥迪沙和锡克姆的M.结核病分离物.
主要方法:
- 来自印度东北部和奥迪沙的102个M.结核病分离体的全基因组测序,再加上来自锡金的7个.
- 对前广泛耐药 (XDR) 和广泛耐药 (XDR) 隔离物的表型药物敏感性测试.
- 变体调用和遗传变异的分析.
主要成果:
- 印度东北部多药耐药结核病 (MDR-TB) 血统2的高患病率 (52/54个隔离点).
- 在奥迪沙州,血统1 (30/48) 和血统3 (11/48) 的混合代表.
- 锡金州的高诺基诺隆耐药性 (51/53个单独体) 和潜在的本地传播.
结论:
- 结核菌的多样性在印度东部地区各不相同.
- 血统2在东北地区占主导地位,而奥迪沙则呈现出混合血统.
- 东北地区的高诺基诺抗性与 gyrA 变异和潜在的本地传播有关.
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