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社会经济地位对内源性疼痛调节的影响:一种准实验方法

Nandini Raghuraman¹, Titilola Akintola², Fenan S Rassu³

¹Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, USA; Graduate Program in Life Sciences, Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, Baltimore, USA; Placebo Beyond Opinions Center, University of Maryland School of Nursing, Baltimore, USA.

The journal of pain

|January 12, 2025

概括

社会经济地位 (SEP) 影响安慰剂缓解疼痛,特别是在慢性疼痛患者中. 痛苦的SEP与临时关节障碍患者的较低安慰剂镇痛有关.

科学领域:

疼痛管理与神经科学
健康差距研究研究研究研究
精神病体医学是一种精神病体医学.

背景情况:

社会经济地位 (SEP),包括教育,收入,职业和社区困境,是已知的慢性疼痛经历的决定因素.
SEP对安慰剂镇痛的影响,由于治疗信念而减少疼痛感知,仍然在很大程度上未被探索.
了解SEP在安慰剂效应中的作用对于解决疼痛差异和制定公平的疼痛管理策略至关重要.

研究的目的:

研究社会经济地位 (SEP) 对关节障碍 (TMD) 和无痛对照患者安慰剂止痛的影响.
探索SEP,遗传因素 (祖先信息标记 - AIMs) 和自我报告的种族在调节安慰剂反应中的相互作用.
为了确定SEP是否与健康个体相比,在慢性疼痛人群中对安慰剂镇痛有不同的影响.

主要方法:

一个准实验性设计,涉及401名患有TMD的参与者和400名没有疼痛的人.
隐性阶级分析被用来根据教育,收入,职业和社区困境指数将参与者分为两个SEP组.
通过口头暗示和经典条件化诱导安慰剂镇痛;统计分析包括线性混合模型和多重回归.

主要成果:

在TMD患者和无疼痛个体之间,安慰剂效应是可比的.
一个趋势表明SEP对安慰剂止痛的主要影响 (p = 0.056).
在TMD参与者中,患有困扰性SEP的患者表现出明显较低的安慰剂止痛效应 (p = 0.005),这种效应在没有疼痛的个人中没有观察到.
东亚血统和自我报告的亚洲种族与更大的安慰剂止痛有关.

结论:

社会经济地位 (SEP) 显著调节安慰剂止痛作用,特别是在患有 TMD 等慢性疼痛疾病的个体中.
痛苦的SEP与TMD患者的安慰剂疼痛缓解受损有关,突出了社会经济因素,慢性疼痛和安慰剂低痛症之间的联系.
遗传和人口因素,包括东亚血统和自我报告的亚洲种族,也影响了安慰剂止痛,强调了疼痛调节的复杂性.

关键词:

祖先信息标记器祖先信息标记调整条件调整条件预期期望预期隐藏类分析隐藏类分析疼痛的严重程度疼痛的严重程度避孕药是一种安慰剂.社会差异社会差异

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