压力控制与压力调节体积控制的儿童通风 (CoCO2) 期间的二氧化碳控制的比较:四级儿科重症监护病房的试点数字随机对照试验协议
Rebeca Mozun1, Daphné Chopard2,3, Florian Zapf2
1Department of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland rebeca.mozuntorrico@kispi.uzh.ch.
BMJ open
|January 12, 2025
概括
这项试点试验测试了一种数字方法,用于比较儿科重症监护中的机械通风. 该研究评估了可行性和二氧化碳控制,为未来的数字重症监护研究铺平了道路.
科学领域:
- 关键护理医学 关键护理医学
- 数字卫生技术数字卫生技术
- 儿科呼吸系统辅助器 儿科呼吸系统辅助器
背景情况:
- 儿科重症监护室 (PICU) 拥有大量的电子数据,但机械通风的数字试验有限.
- 在PICU中最佳的机械通风策略需要进一步的证据.
- 数字试验提供了效率的好处,并可以扩大干预措施的证据基础.
研究的目的:
- 为了测试数字儿科重症监护室 (PICU) 试验的可行性.
- 为了比较使用二氧化碳 (CO2) 控制的两个侵入性机械通风模式.
- 在重症儿童中评估目标二氧化碳范围内的坚持和时间.
主要方法:
- 一个单中心的,开放的,随机的试验试验,比较压力控制和压力调节的体积控制通风.
- 纳入标准:年龄小于18岁,体重大于2kg,动脉线,通风时间大于60分钟;排除标准:心脏分流,肺高血压,内高血压.
- 通过连续的潮尾/透皮和间歇性血液气体分析进行CO2监测;从电子健康记录中收集的数据.
主要成果:
- 主要可行性结果:遵守分配的通风模式.
- 主要生理结果:在目标二氧化碳范围内的时间比例 (normocarbia).
- 数据每分钟以数字方式捕获;计划对60名注册患者进行治疗意向分析.
结论:
- 这种数字试验设计可用于评估重症儿童的机械通风.
- 这项研究为儿科重症监护中更大规模,务实的数字试验提供了基础.
- 这些发现将为在PICU设置中机械通风期间的最佳CO2管理策略提供信息.
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