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肝功能和阿尔茨海默氏症的大脑病理:一个纵向研究:肝脏和阿尔茨海默氏症的病理

Jee Wook Kim¹, Min Soo Byun², Dahyun Yi³

¹Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, 7 Keunjaebong-gil, Hwaseong, Gyeonggi, 18450, Republic of Korea; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Gangwon, 24252, Republic of Korea.

The journal of prevention of Alzheimer's disease

|January 12, 2025

概括

这项研究发现,肝功能变化,特别是更高的氨酸转移酶和更低的总胆红素,与阿尔茨海默氏病 (AD) 病理,如粉样蛋白和陶积累的增加相关.

科学领域:

神经科学是一个神经科学.
肝病学肝病学是一种肝病学.
老年学是指老年学的学科.

背景情况:

肝功能与阿尔茨海默氏症 (AD) 神经病理学之间的联系仍然不清楚.
了解这种联系对于识别AD的新疗法目标至关重要.

研究的目的:

研究肝功能标志物与核心阿尔茨海默病病理学的进展之间的关系.
探索肝脑轴在AD病变发生过程中的潜在作用.

主要方法:

纵向队列研究 (韩国大脑衰老研究) 涉及347名老年人.
基线和2年随访评估包括肝功能测试 (ALT,AST,总胆红素) 和脑成像 (粉胺-PET,tau-PET,FDG-PET,MRI).

主要成果:

氨氨基转移酶 (ALT) 的升高与2年内的β-粉样蛋白沉积增加有关 (P_B = 0.012).
在同一时期,较低的总 bilirubin 水平与 tau 沉积的较大增加相关 (P_{B_0.001).}
酸氨基转移酶 (AST) 与AD病理变化没有显著的关联.

结论:

降低肝功能可能与阿尔茨海默氏症关键病理学的积累有关.
肝-脑轴为阿尔茨海默病的潜在治疗或预防目标.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.这就是Aββ的意思.氨酸氨基转移酶是一种氨酸氨基转移酶.知道的知道的知道的总比利鲁宾的总量

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