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一种新的3D打印样品制备方法,用于在人血清中定量二胺

Dagmara Kroll¹, Szymon Ulenberg¹, Paweł Georgiev¹

¹Department of Pharmaceutical Chemistry, Medical University of Gdansk, Hallera 107, 80-416, Gdansk, Poland.

Analytica chimica acta

|January 12, 2025

概括

这项研究引入了3D打印设备,用于从人血清中高效地分析二. 这种新的方法减少了样品和溶剂量,为药物监测提供了一个环保的替代方案.

科学领域:

分析化学分析化学
材料科学材料科学材料科学
法医毒理学法医毒理学

背景情况:

滥用二是主要的公共卫生问题.
现有的样品制备方法很复杂,需要大量的样品,并且使用过多的溶剂.
需要更高效和可持续的分析技术.

研究的目的:

开发和验证一种新的,高效的样品制备方法,用于二胺分析.
利用3D打印的吸附剂设备从人体血清中提取二.
为了克服传统样品准备技术的局限性.

主要方法:

使用C18修饰的二氧化热塑性复合材料制造3D打印 Sorbent 装置.
根据ICH指南,优化和验证提取方法.
在人血清中使用LC-MS进行定量二胺分析的方法的应用.

主要成果:

这些3D打印设备在提取二类药物方面表现出高效率.
该方法需要最小的样品和溶剂体积.
消除了蛋白质沉,蒸发和溶解的步骤,简化了工作流程.

结论:

这种新的3D打印 Sorbent 装置提供了一种更高效,更环保的方法来分析二.
3D打印技术可以为各种分析剂和矩阵提供可定制的吸附器件.
这种方法与LC-MS相结合,为二胺的临床和毒理监测提供了一个敏感的工具.

关键词:

通过3D打印打印3D打印.这种药物是Benzodiazepines.化沉积物的建模.人类血清的人类血清样品的准备样品的准备固体阶段微提取的微提取方法

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