固体器官移植受体中中枢神经系统感染
Oscar Morado-Aramburo1, Leeja Joseph1, Harmanpreet Kaur1
1Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.
Transplantation proceedings
|January 12, 2025
概括
固体器官移植 (SOT) 接受者的中枢神经系统 (CNS) 感染很少发生,但严重. 真菌感染,特别是Cryptococcus neoformans,是最常见的,发烧表明不良结果的风险更高.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 神经学 神经学
背景情况:
- 中枢神经系统 (CNS) 感染对实体器官移植 (SOT) 接受者构成严重风险.
- 了解这些感染的流行病学和结果对于患者管理至关重要.
研究的目的:
- 描述SOT接受者中中枢神经系统感染的流行病学,临床表现,诊断,病程和结果.
- 为了确定与本种人群中中枢神经系统感染相关的常见病因和危险因素.
主要方法:
- 从2012年9月至2023年2月期间被诊断患有中枢神经系统感染的SOT患者的病历数据的回顾性分析.
- 纳入标准:接受SOT并在该机构诊断/治疗中枢神经系统感染的患者.
主要成果:
- 在1345名SOT接受者中,中枢神经系统感染发生在2.23%的人中.
- 真菌感染 (50%),主要是Cryptococcus neoformans (46.6%),是最常见的原因.
- 发烧 (60%) 与不良结果的风险增加有关 (OR 11;P = .018),其中33%的人经历了不良结果和6.7%的死亡率.
结论:
- 在SOT接受者中,中枢神经系统感染很少发生,但与显著的不良结果有关.
- 菌病原体是主要的原因,强调了针对性抗真菌策略的必要性.
- 早期识别发烧等症状对于改善患者的治疗结果至关重要.
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