在晚期黑色素瘤进展后,患者对持续免疫检查点抑制的看法:一种定性研究
Chloé Prod'homme1, Nicolas Sena1, Emmanuelle Forestier1
1Palliative Care Unit, ULR 2694 METRICS, CHU de Lille, Université de Lille, 59000 Lille, France.
Bulletin du cancer
|January 12, 2025
概括
晚期黑色素瘤患者在接受持续免疫检查点抑制剂以及息治疗的同时报告了改善的幸福感. 这种综合的方法,平衡希望和终身现实,尽管存在疾病进展的挑战,但得到了很好的接受.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 黑色素瘤研究 黑色素瘤研究
背景情况:
- 免疫检查点抑制剂 (ICI) 是转移性黑色素瘤的标准,即使在晚期.
- 晚期疾病的持续ICI治疗带来风险:不必要的副作用,延迟的息护理准入和增加的成本.
- 患者对持续ICI和息治疗的看法对于优化生命终端管理至关重要.
研究的目的:
- 探索持续免疫检查点抑制剂与转移性黑色素瘤的专家息治疗相结合的患者经验.
- 从患者的角度了解这种综合护理方法的感知优点和缺点.
主要方法:
- 定性研究涉及10名患有转移性黑色素瘤的患者,接受综合治疗.
- 深度采访分析采用基于理论的方法.
- 遵守COREQ (报告定性研究的综合标准) 的指导方针.
主要成果:
- 收到疾病进展和息护理消息的患者面临焦虑和痛苦,但发现联合管理改善了福祉.
- 尽管临近死亡的"达摩克勒斯之剑",但患者的日常生活和整体幸福感得到了改善.
- 结合瘤与息护理的方法得到了很好的接受,抵消了潜在的绝望.
结论:
- 患者的经验揭示了矛盾,平衡痛苦与生活的愿望和保持希望.
- 联合瘤学和息护理团队可以象征希望和死亡,反映患者的心理状态.
- 综合护理模式通过解决疾病和患者的生存需求,提供必要的支持.
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