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小脑和中部前额叶皮层在自适应性运动定时中的神经动态

Zhong Ren¹, Xiaolu Wang¹, Milen Angelov¹

¹Department of Neuroscience, Erasmus MC, Westzeedijk 353, 3015 AA, Rotterdam, the Netherlands.

Nature communications

|January 12, 2025

概括

中间前额叶皮层 (mPFC) 快速适应运动时间,而小脑间接核 (IpN) 显示不对称的适应. 沉默mPFC阻止了这个时间调整.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
发动机控制器的控制器

背景情况:

精确的时间控制对于动物的感觉运动协调和适应至关重要.
了解不同大脑区域的灵活时间适应的神经机制是必不可少的.

研究的目的:

在延迟眼条件 (DEC) 和痕迹眼条件 (TEC) 之间的时间适应过程中,研究小脑间插入核 (IpN) 和中间前额皮质 (mPFC) 的神经动态.
阐明mPFC和Ipn在自适应电机定时中的不同作用.

主要方法:

鼠被训练在DEC或TEC中,然后切换到另一个范式.
在这些适应任务期间,IPN和mPFC中的神经元活动被记录下来.
为了评估其在适应中的作用,mPFC被沉默了.

主要成果:

条件响应 (CRs) 在转换范式时几乎瞬间适应.
与CR定时相关的IPN神经元活动变化在DEC-to-TEC适应过程中突出,但在TEC-to-DEC适应过程中不那么突出.
mPFC神经元在两个适应方向上迅速改变了它们的调制模式,mPFC沉默完全取消了CR定时适应.

结论:

在条件反应的快速,灵活的时间适应中,mPFC起着至关重要的作用.
脑 (IpN) 和大脑 (mPFC) 机制在控制关联运动时间方面表现出不同的动态和作用.
这些发现凸显了小脑和mPFC对自适应运动时间的独特贡献.

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