口腔上皮细胞与年龄相关的变化对儿科表观遗传生物标志物研究的影响
Sarah M Merrill1,2, Chaini Konwar2,3,4, Fizza Fatima2,3,4
1Department of Psychology, University of Massachusetts Lowell, Lowell, MA, USA.
Nature communications
|January 12, 2025
概括
脸抽样中的口腔细胞比例随着儿童的年龄而下降,这影响了DNA甲基化研究. 适应这种变化对于准确的表观遗传年龄和儿科生物标志物研究至关重要.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 基因组学就是基因组学.
背景情况:
- 在儿科DNA甲基化研究中,脸扫描很常见.
- 大人的口腔细胞与年龄相关的下降是已知的,但未在儿童中进行检查.
- 了解口腔细胞组成的变化对于精确的表观遗传研究至关重要.
研究的目的:
- 调查儿童口腔细胞比例与年龄相关的变化.
- 评估口腔比例对表观遗传年龄估计及其关联的影响.
- 在儿科表观遗传学研究中确定校正口腔比例的必要性.
主要方法:
- 分析了4626名2个月至20岁儿童的脸抽样样本.
- 在样本中估计口腔和中性粒细胞比例.
- 细胞比例,时间年龄和表观遗传年龄之间的相关性分析 (PedBE).
主要成果:
- 在儿童中,口腔比例随着时间和表观遗传年龄的增长而下降,但在青春期并非如此.
- 中性粒细胞比例显示与年龄的反向关系.
- 对口腔比例的纠正减少了表观遗传衰老加速与某些健康结果之间的关联,同时加强了其他结果.
结论:
- 在儿童中,口腔细胞组成的与年龄相关的变化是显著的.
- 考虑到口腔比例对于精确的儿科DNA甲基化和表观遗传年龄研究至关重要.
- 这种调整完善了与健康和发育有关的表观遗传衰老加速的解释.
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