青少年异常性关节炎患者在怀孕期间的生育能力,怀孕结果和疾病活动:一项描述性研究
Ali İhsan Sonkurt1, Gül Doğan1, Kerem Parlar1
1Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Clinical rheumatology
|January 12, 2025
概括
青春期异常性关节炎 (JIA) 并没有显著影响生育能力或增加怀孕期间的风险. 患有JIA的患者通常可以生孩子,而不必担心他们的病情会影响怀孕结果.
科学领域:
- 类风湿病学 类风湿病学
- 生殖健康 生殖健康
- 儿科风湿病学 儿科风湿病学
背景情况:
- 青少年异常性关节炎 (JIA) 是一种慢性自身免疫性疾病,影响儿童,许多患者过渡到成人护理.
- 了解JIA对成人生育能力和怀孕结果的影响,对于患者的咨询和管理至关重要.
研究的目的:
- 评估有JIA病史的成年患者的生育状况.
- 评估JIA患者怀孕期间和怀孕后的妊娠结果和疾病活性.
- 确定JIA是否影响生殖健康和妊娠并发症.
主要方法:
- 对141名被诊断为JIA的成年患者进行了回顾性研究.
- 通过医疗记录和患者访谈收集数据,包括人口统计数据,病史,生育能力和怀孕结果.
- 使用费舍尔精确测试来比较分类变量 (p < 0.05显著性) 的统计分析.
主要成果:
- 19名女性和6名男性JIA患者试图怀孕;大多数成功地成为父亲/没有辅助生殖技术的孩子.
- 不孕不育的发病率低 (1/25名患者).
- 观察到的妊娠并发症包括流产 (17.4%),妊娠前 (4.3%),早产 (4.3%) 和妊娠糖尿病 (4.3%). 疾病爆发发生在32.2%的怀孕中.
结论:
- 在男性和女性患者中,JIA对生育能力的影响很小.
- JIA并没有显著增加不良妊娠结果或并发症的风险.
- JIA患者的疾病活动在怀孕期间和产后通常是可以管理的,这表明患者可以自信地继续怀孕.
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