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分子识别和Fusarium spp.的抗真菌敏感性. 临床隔离物临床隔离物

Carla M Román-Montes^1,2, Fernanda González-Lara^1,2, Paulette Diaz-Lomelí¹

¹Clinical Microbiology Laboratory, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

|January 12, 2025

概括

分子鉴定揭示了Fusarium petroliphilum作为墨西哥最常见的Fusarium物种. 尽管抗真菌敏感性测试 (AST) 不超过截止值,但菌病例的死亡率很高.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
分子诊断学分子诊断

背景情况:

准确识别Fusarium物种对于有效治疗fusariosis至关重要.
抗真菌耐药性和治疗失败使菌病管理复杂化.
关于墨西哥的Fusarium流行病学和抗真菌敏感性测试 (AST) 的数据有限.

研究的目的:

分析在墨西哥使用DNA测序的Fusarium物种分布.
为了将抗真菌敏感性测试 (AST) 的结果与菌病的临床结果相关联.

主要方法:

对临床Fusarium分离物的回顾性研究.
通过翻译延长因子-1α基因测序进行分子鉴定.
抗真菌敏感性测试 (AST) 用于确定最小抑制度 (MIC).

主要成果:

最常见的是Fusarium solani物种复合体 (FSSC) (51.5%),其中最常见的是Fusarium petroliphilum (37%) 和Fusarium oxysporum (20%).
没有MIC超过了流行病学截止值.
19名患者 (主要是血液性瘤患者) 发生了病,死亡率为32%.

结论:

在FSSC内,Fusarium petroliphilum是被确定的主要物种.
在菌病患者中观察到较高的死亡率.
与F. oxysporum SC和F. fujikuroi SC相比,F. solani SC的MIC50值较高,而F. oxysporum SC和F. fujikuroi SC的MIC50值较高.

关键词:

这里是 Fusariumarium .类植物的原始生长抗真菌易感性复杂的 Fusarium 物种群.菌性感染菌性感染融合的意思就是融合.分子识别分子识别翻译延长因子-1αα.

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