Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antibiotic Selection00:57

Antibiotic Selection

52.2K
Overview
52.2K
Antimicrobial Proteins01:23

Antimicrobial Proteins

887
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
887

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Graph Neural Network-Assisted Machine Learning for High-Throughput Buried Interfacial Materials Screening in Antisolvent-Free Perovskite Solar Cells.

ACS applied materials & interfaces·2026
Same author

Reducing P-O bond covalency in polyanionic groups to increase the intrinsic electronic conductivity in sodium positive electrodes.

Nature communications·2026
Same author

High-Performance Flexible Electromagnetic Wave Absorber through Synergistic Regulation of Matching and Reflective Layers.

ACS applied materials & interfaces·2026
Same author

Analysis of the effect of variable frequency fan on tobacco metabolites during curing via untargeted metabolomics.

BMC plant biology·2026
Same author

Heuristic multi-site optimization for protein sequence design using Masked Protein Language Models.

PLoS computational biology·2026
Same author

A prediction nomogram for faltering catch-up growth in full-term small-for-gestational-age infants: a retrospective cohort study.

Frontiers in pediatrics·2026
Same journal

STED: flexible cross-modal topic modeling infers cell-type-specific regulatory landscapes from bulk epigenomics.

Briefings in bioinformatics·2026
Same journal

A knowledge-guided deep learning framework for quantitative nucleic acid testing.

Briefings in bioinformatics·2026
Same journal

Optimal transport for label transfer in single-cell multi-omics integration.

Briefings in bioinformatics·2026
Same journal

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same journal

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same journal

Transformers for single-cell RNA sequencing: a survey.

Briefings in bioinformatics·2026
查看所有相关文章

相关实验视频

Updated: Jun 3, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.4K

使用多目标的零阶优化,针对抗微生物的定向进化.

Xianliang Liu1, Jiawei Luo1, Xinyan Wang2

  • 1School of Computer Science and Technology, Harbin Institute of Technology, HIT Campus, Shenzhen University Town, Nanshan District, Shenzhen 518055, Guangdong, China.

Briefings in bioinformatics
|January 12, 2025
PubMed
概括
此摘要是机器生成的。

PepZOO通过在连续空间中探索属性变化来优化抗菌 (AMP),优于现有的方法. 这种新的方法加速了有效和安全的治疗的发现.

关键词:
抗微生物类的抗微生物.指导进化是指导进化的.零级优化的优化.

更多相关视频

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
09:01

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli

Published on: March 16, 2011

30.4K
A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
13:30

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes

Published on: November 7, 2012

18.0K

相关实验视频

Last Updated: Jun 3, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.4K
Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
09:01

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli

Published on: March 16, 2011

30.4K
A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
13:30

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes

Published on: November 7, 2012

18.0K

科学领域:

  • 生物化学和计算化学.
  • 药物的发现和开发.
  • 生物信息学和机器学习

背景情况:

  • 抗微生物 (AMP) 显示出治疗前景,但需要优化以提高活性和降低毒性.
  • 由于离散序列空间探索,AMPs的现有优化算法通常具有低效率,有限的多样性和局部最佳值.

研究的目的:

  • 介绍PepZOO,一种用于优化AMP多特性的新型定向进化方法.
  • 通过在连续表示空间中运行来解决以前方法的局限性.

主要方法:

  • 佩普ZOO使用一个变量自编码器将AMPs投射到连续的潜空间中.
  • 多目标零级优化指导AMP优化潜在嵌入的代更新.
  • 分子对接和动力学模拟验证了优化的AMP.

主要成果:

  • 在增强AMP的抗微生物功能,活性,毒性概况和向结合亲和力方面,PepZOO表现出优于最先进的方法的卓越性能.
  • 该方法成功地确定了关键动机,这些动机对于在进化过程中保持特定的性质至关重要.
  • PepZOO通过专注于属性优化,加速发现潜在的治疗性.

结论:

  • PepZOO通过将重点从序列突变转移到属性探索,为AMP优化提供了一个新的范式.
  • 这种方法提高了发现新型治疗的效率和多样性.
  • 该方法验证了连续表示和AMP设计多目标优化的有效性.