能力与死亡风险之间的关联:饮食和衰老的作用
Mi Du1, Ke Deng2, Jiawei Yin3
1School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China.
Journal of clinical periodontology
|January 13, 2025
概括
能力受损 (ICC) 与饮食不良和更快的衰老有关,增加死亡风险. 对饮食和口腔健康的干预可能会促进长寿.
科学领域:
- 老年学是指老年学的学科.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 失去牙和口功能障碍是死亡的可修改风险因素.
- 能力与死亡率相关的特定途径,涉及饮食和衰老,需要研究.
研究的目的:
- 检查饮食质量和生物衰老在能力和长期死亡率之间的关联中的作用.
- 评估饮食和衰老对与能力受损相关的死亡风险的影响.
主要方法:
- 使用NHANES数据 (1999-2010年) 进行前性研究,并对死亡率进行到2019年的跟踪 (n=22,900).
- 用功能牙单位 (FTU) 评估的能力.
- 用营养指数 (NI),E-DII和HEI-2015来衡量饮食质量. 生物衰老通过PhenoAgeAccel和脆弱指数进行评估. 进行的调解分析.
主要成果:
- 较高的FTU与较慢的生物衰老相关.
- 饮食质量介导了9.0%-23.0%的能力和生物衰老之间的关联.
- 能力受损 (ICC) 显著增加了全因死亡率 (HR=1.282),心血管疾病死亡率 (28.9%) 和癌症死亡率 (32.7%).
- 芬诺AgeAccel和脆弱指数调解了ICC对死亡率的影响 (11.6%-23.5%).
结论:
- 能力受损与饮食质量低下和加快衰老有关,导致死亡风险增加.
- 饮食干预和口腔康复是促进健康寿命的潜在策略.
- 需要进一步的研究来证实这些发现和干预的有效性.
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