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双重感官障碍和痴呆症之间的关联:系统性审查和元分析

Yuto Yoshida¹, Yoshimune Hiratsuka¹, Reiko Umeya²

¹Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.

Journal of Alzheimer's disease : JAD

|January 13, 2025

概括

双重感官障碍 (DSI) 影响视力和听力,显著增加痴呆风险. 这包括阿尔茨海默病,但不包括血管痴呆症,突出了预防策略的必要性.

科学领域:

神经科学是一个神经科学.
流行病学流行病学
公共卫生公共卫生

背景情况:

感官障碍是痴呆的已知的危险因素.
双重感官障碍 (DSI),包括视力和听力损失,对痴呆风险的具体影响仍然不清楚,因为研究结果不一致.

研究的目的:

系统地审查和综合现有证据,关于双重感官障碍和痴呆症发病率之间的关联.

主要方法:

在主要数据库 (MEDLINE,EMBASE,Cochrane图书馆) 进行了全面的文献搜索.
包括的研究包括前性和后性队列研究,以及病例控制研究.
对危险比率 (HRs) 的元分析使用随机效应模型进行,以确定整体效应大小.

主要成果:

分析了11项涉及346,659名参与者的观察性研究.
DSI与痴呆症发病率的增加显著相关 (HR: 1.46; 95% CI: 1.29-1.65).
在DSI和阿尔茨海默氏症发病之间观察到显著的关联 (HR: 2.07;95% CI: 1.45-2.94),但不是血管痴呆症 (HR: 1.65;95% CI: 0.96-2.85).

结论:

双重感官障碍是发展痴呆症的重要危险因素.
进一步的研究至关重要,以开发针对有感官障碍的人群的有针对性的预防干预措施,以减少痴呆症的发生率.

关键词:

阿尔茨海默病的疾病阿尔茨海默病的疾病.痴呆症痴呆症是一种痴呆症.双重感官障碍是一种双重感官障碍.听力损伤听力损伤视力受损视力受损视力受损

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