关节疾病和COVID-19风险之间是否存在因果关系? 一个遗传仪器变量分析分析
1Department of Stomatology, Suzhou Wujiang District Hospital of Traditional Chinese Medicine, 215221 Suzhou, Jiangsu, China.
Journal of oral & facial pain and headache
|January 13, 2025
概括
这项研究发现COVID-19和关节疾病 (TMD) 之间没有因果关系. 双向门德尔随机化分析表明,这两种情况都没有影响对方,这表明心理压力可能是一个因素.
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 冠状病毒疾病2019 (COVID-19) 流行病使公众对关节疾病 (TMD) 的关注度增加.
- 以前的流行病学研究表明,在COVID-19大流行时代,TMD患病率可能会上升.
- 了解COVID-19和TMD之间的病因关系对于公共卫生至关重要.
研究的目的:
- 通过双向孟德尔随机化 (MR) 调查COVID-19和关节疾病 (TMD) 之间的潜在因果关系.
- 为了确定COVID-19是否影响TMD易感性或TMD是否影响COVID-19风险.
- 消除反向因果关系和混因素,提供病因学证据.
主要方法:
- 利用来自COVID-19宿主遗传计划 (HGI) 的全基因组关联研究 (GWAS) 数据用于COVID-19表型和英国生物银行 (UKB) 的TMD.
- 采用双向门德尔随机化 (MR) 分析,包括反变量加权 (IVW),加权中位数 (WM) 和MR-Egger回归.
- 进行了灵敏度分析 (MR-PRESSO,科克兰的Q测试,MR-Egger拦截,留出一个) 并用FinnGen GWAS数据验证了发现.
主要成果:
- 双向MR分析显示TMD对COVID-19易感性没有显著的因果作用.
- 反向MR分析表明,COVID-19对TMD没有显著的因果作用.
- 灵敏度分析证实了可靠的结果,没有显示出性质的证据,尽管统计能力受到样本大小的限制.
结论:
- 目前的证据表明,COVID-19没有影响TMD,也没有增加TMD对严重急性呼吸综合征冠状病毒-2的易感性.
- 与COVID-19流行病相关的心理压力可能在这些条件之间的关系中起到调解作用.
- 需要进一步的外部研究来最终验证COVID-19和TMD之间的关系.
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