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Updated: Jun 3, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

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来自Tepidiphilus thermophilus的自给自足细胞染色体P450和ilaprazole之间的生物物理相互作用

Jaejeong You1, Yunha Hwang1, Yeon-Ju Jeong2

  • 1Department of Chemistry, Jeonbuk National University, Jeonju 54896, Republic of Korea. slee026@jbnu.ac.kr.

Dalton transactions (Cambridge, England : 2003)
|January 13, 2025
PubMed
概括

这项研究表明,CYP116B46是了解质子抑制剂 (PPI) 代谢的良好模型. 它有助于研究像伊拉普拉和细胞染色体P450酶等PPI之间的相互作用.

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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells08:38

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相关概念视频

Drug Metabolism: Phase I Reactions01:17

Drug Metabolism: Phase I Reactions

A phase I reaction is a biochemical process that introduces a functionally reactive polar group to a substance. This transformation predominantly occurs in the liver, facilitated by the cytochrome P450 system of hemoproteins situated in the lipophilic endoplasmic reticulum of cells. The metabolite generated through this process can have varying polarities. If it is sufficiently polar, it can be easily excreted in the urine due to its water compatibility. However, if the metabolite is nonpolar,...
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