血压和不良健康结果的目标范围中的时间:系统性审查
Huairong Wang1, Jialu Song1, Zhike Liu1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.).
Hypertension (Dallas, Tex. : 1979)
|January 13, 2025
概括
目标血压范围 (TTR) 的较高时间显著降低了所有原因死亡率,心血管死亡,主要心血管不良事件和心力衰竭的风险. 持续控制血压对于更好的健康结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 高血压管理 高血压管理
- 公共卫生 公共卫生
背景情况:
- 目标范围内的血压 (BP) 时间 (TTR) 量化了BP控制持续时间.
- 了解TTR对健康结果的影响对于临床实践至关重要.
研究的目的:
- 系统地审查和元分析TTR与各种不良健康结果之间的关联.
- 总结目前关于血压控制持续时间和健康风险之间的关系的证据.
主要方法:
- 对七个数据库进行了全面的搜索.
- 对21项研究的数据进行了元分析,评估了TTR与死亡率和发病率的关联.
- 研究的质量和偏差风险都得到了评估.
主要成果:
- 较高的TTR,特别是在110-130 mmHg和120-140 mmHg范围内的缩血压 (SBP) 和70-80 mmHg范围内的腹缩血压,与显著降低的风险有关.
- 观察到所有原因死亡率 (HR 0.85-0.81),心血管死亡 (HR 0.83-0.76),主要心血管不良事件 (HR 0.76) 和心力衰竭 (HR 0.84-0.78) 的具体减少.
- 在TTR和心肌梗塞,中风,心房动或脏不良事件之间没有发现显著的关联.
结论:
- 升高的TTR与死亡率和主要心血管事件的风险降低有关.
- 通过更高的TTR保持持续的血压控制对于改善患者的治疗结果很重要.
- 这些发现强调了一致的BP管理的临床意义.
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