如何将心胸干预后的生存率置于一般人群的背景下:基于案例的实际指南来计算累积匹配的一般人群生存率
Xu Wang1, Maximiliaan L Notenboom1, Kevin M Veen1
1Department of Cardiothoracic Surgery (X.W., M.L.N., K.M.V., P.G., J.R.G.E., A.J.J.C.B., J.J.M.T.), Erasmus University Medical Center, Rotterdam, The Netherlands.
Circulation. Cardiovascular quality and outcomes
|January 13, 2025
概括
将心胸外科手术后的患者存活率与一般人群存活率进行比较需要仔细匹配. 这项研究表明,匹配方法显著影响生存估计,特别是在老年患者中.
科学领域:
- 心胸外科手术 心胸外科手术
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 心胸干预后的患者存活率需要从一般人口存活率的背景中考虑.
- 准确的比较需要方法来将一般人口的死亡率与患者队列相匹配.
研究的目的:
- 概述和评估将一般人口死亡率与患者存活率数据相匹配的方法.
- 计算累积匹配的一般人群生存率,并根据匹配策略评估其可变性.
主要方法:
- 利用了罗斯手术幸存者的多中心数据集.
- 从人类死亡率数据库生命表中提取了一般人口的死亡率.
- 应用各种匹配策略,考虑年龄,日历年,国家和性别.
主要成果:
- 包括来自5个国家的1431名医院幸存者.
- 15年生存率为88.3%;累计匹配的一般人口生存率从87.7%到89.8%不等.
- 根据匹配的复杂性,对老年患者 (67.4%-59.8%) 和年轻患者 (96.9%-96.7%) 的估计差异很大.
结论:
- 用于将一般人口死亡率与患者存活率收益率变量估计相匹配的方法.
- 建议考虑国家,性别,个体年龄和日历年份进行全面匹配.
- 基于Web的闪亮应用程序可用于计算累积匹配的一般人口生存率.
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