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微生物组和炎症生物标志物与部伤口愈合相关
Mauro Pedrine Santamaria1,2, Ingrid Fernandes Mathias-Santamaria1, Ana Carolina Ferreira Bonafé2
1College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.
Journal of periodontal research
|January 13, 2025
概括
特定的口腔微生物组和炎症概况与口腔手术后的预期和不预期的伤口愈合有关. 了解这些因素可以改善接受自由牙移植 (FGG) 的患者的临床结果.
科学领域:
- 在口腔外科手术中.
- 伤口愈合 伤口愈合
- 微生物组研究的研究.
- 炎症生物标志物 炎症生物标志物
背景情况:
- 外科手术的临床结果受到组织修复变化的影响.
- 主体炎症反应和微生物群之间的相互作用影响口腔粘膜的愈合.
- 在 palatal 伤口愈合中理解这些因素存在一个差距.
研究的目的:
- 评估患者的微生物组和生物标志物概况,以期望和不希望的 palatal 伤口愈合.
- 研究特定的微生物和炎症概况与伤口愈合结果之间的关联.
主要方法:
- 研究了17名接受免费牙移植 (FGG) 的患者,以保护牙.
- 在临床上评估了口伤口关闭 (WC) 和上皮化 (EPT).
- 在手术后的多个时间点收集和分析生物膜和炎症排泄物.
主要成果:
- 两组之间没有观察到阿尔法多样性的显著差异.
- 贝塔多样性显示了两组微生物组的变化,在第30天恢复到基线.
- 不必要的愈合 (UH) 与与上皮层入侵,毒性和口腔疾病相关的微生物有关,同时增加了IL-6,MCP-1和MIP-1α.
- 期望的愈合 (DH) 显示出平衡的微生物组和明显的炎症概况,TIMP-1,IL-1β和MIP-1α降低,MIP-1α和MMP-2在3-7天增加.
结论:
- 显著的微生物组和炎症概况与所需和不需要的伤口愈合有关.
- 这些发现突出了预测和管理 palatal 伤口愈合结果的潜在生物标志物.
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