异常运动心电图与正常压力心声图与亚临床冠状动脉样硬化有关
Jessica M Duran1, Peter Shrader2, Chuan Hong2,3
1Division of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (J.M.D.).
Circulation. Cardiovascular imaging
|January 13, 2025
概括
运动心电图异常但压力回声正常的患者冠状动脉样硬化负担更高. 这一发现可能解释了他们患心血管不良事件的风险增加.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 预防性心脏病学 预防性心脏病学
背景情况:
- 不正常的运动心电图 (ECG) 与正常的应力心电图 (+ECG/-Echo) 与心血管事件风险增加有关.
- 这种心电图/回声失调与亚临床冠状动脉样硬化负担之间的关联尚不清楚.
研究的目的:
- 调查+ECG/-Echo异调是否与亚临床冠状动脉样硬化的更大负担有关.
- 为了比较患有异调 (+ECG/-Echo) 和一致正常 (-ECG/-Echo) 应力回声结果的患者之间的冠状动脉 (CAC) 评分.
主要方法:
- 从项目基线健康研究中分析了无症状的参与者,他们接受了压力回声和CAC扫描.
- 参与者的分层分为-ECG/-Echo和+ECG/-Echo组.
- 多变量回归以评估应力回声结果与CAC负担之间的关联,并根据相关因素进行调整.
主要成果:
- 与 -ECG/-Echo组相比,+ECG/-Echo组的冠状动脉样硬化负担显著增加 (CAC平均得分为198±470而不是53±186).
- 具有+ECG/-Echo的参与者CAC=0的可能性较小 (53.3%对65.9%),CAC≥100的可能性更高 (28.6%对11.4%).
- 调整后的分析显示,在+ECG/-Echo组中,日志转换CAC得分高出52%,CAC ≥400的可能性增加了4.5倍.
结论:
- +ECG/-Echo的个体表现出较高的亚临床冠状动脉样硬化负担.
- 这种增加的动脉样硬化可能部分解释了在这个人群中观察到的心脏不良事件的风险增加.
- 进一步的研究是有必要的,以建立最佳的心血管风险减轻策略的+ECG/-Echo异调的患者.
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