在糖尿病病诊断模型中实施新的全血细胞计衍生炎症指数
Ali Hassanzadeh1, Mehdi Allahdadi2, Sepehr Nayebirad3
1Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Shahrivar Alley, Kargar St., Tehran, 1411713119 Iran.
Journal of diabetes and metabolic disorders
|January 13, 2025
概括
像RDW这样的血图标记在诊断2型糖尿病 (T2DM) 患者的糖尿病病 (DKD) 上具有有限的影响. 虽然红细胞分布宽度改善了后勤回归模型的重新分类,但其他标记物并没有显著提高诊断性能.
科学领域:
- 血液学 血液学 血液学
- 糖尿病学 糖尿病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 血液图上的炎症标志物,包括中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),红细胞分布宽度 (RDW) 和平均血小板体积 (MPV),与2型糖尿病 (T2DM) 和糖尿病病 (DKD) 有关.
- 评估这些标志物的诊断效用与人口和临床特征相结合,对于理解T2DM并发症至关重要.
研究的目的:
- 开发和验证2型糖尿病患者糖尿病病 (DKD) 的逻辑回归 (LR) 和CatBoost诊断模型.
- 评估将血图炎症标志物 (NLR,PLR,RDW,MPV) 添加到这些诊断模型中的增量值.
主要方法:
- 开发基线LR和CatBoost模型,使用来自1011名T2DM患者的人口,临床和实验室数据.
- 模型性能 (AUC-ROC,NRI,IDI) 的比较,包括和不包括NLR,PLR,RDW和MPV.
- 列车测试分割和数据预处理用于模型验证.
主要成果:
- 在LR (AUC-ROC:0.738) 和CatBoost (AUC-ROC:0.715) 基线模型中,表现相似.
- 添加炎症标志物并没有显著改善两种模型的整体AUC-ROC.
- 红细胞分布宽度 (RDW) 添加到LR模型中改善了非DKD患者的重新分类,但增加了DKD病例的错误分类;其他标志物在NRI或IDI中没有显著改善.
结论:
- 结合人口和临床特征的基线模型在T2DM中为DKD评估提供了可接受的性能.
- 虽然RDW在LR模型中显示了改善非DKD个体重新分类的潜力,但其添加以及其他标记物并没有显著提高评估模型的整体诊断准确性.
相关概念视频
Acute Kidney Injury IV: Diagnostic Studies and Prevention
582
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
582
Chronic Kidney Disease I: Introduction
1.4K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K
Chronic Kidney Disease III: Interprofessional Care
706
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
706
Diabetic Nephropathy
52
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
52


