分析韩国临床试验中的合作,使用关联规则挖矿
Ki Young Huh1,2, Ildae Song3
1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.
Translational and clinical pharmacology
|January 13, 2025
概括
协会规则挖掘揭示了临床试验中的独特合作模式. 与其他阶段相比,第一阶段试验展示了更多的独家现场合作.
科学领域:
- 临床试验管理 临床试验管理
- 数据挖掘 数据挖掘
- 医疗信息学 医疗信息学
背景情况:
- 了解多中心试验场所之间的合作对于高效的试验执行至关重要.
- 根据研究阶段和治疗领域,合作动态可能会有所不同.
- 协会规则挖掘为分析这些复杂的关系提供了一种新的方法.
研究的目的:
- 确定和描述韩国临床试验场所之间的合作模式.
- 探索协作在不同研究阶段和临床试验领域如何变化.
- 为了利用协会规则挖掘来发现隐藏的试验站点网络.
主要方法:
- 利用韩国食品和药物安全部 (2012-2023) 的试验批准数据.
- 员工协会规则挖掘分析协作网络.
- 根据研究阶段和领域对11,107项临床试验进行了分类,涉及209个试验地点.
主要成果:
- 与第二阶段 (1.68) 和第三阶段 (1.72) 试验相比,第一阶段试验显示出明显更高的提升指标 (平均5.40),表明更多的独家合作.
- 第一阶段试验协作网络高度紧缩,特别是在首尔和 Gyeonggi-do.
- 儿科临床试验领域在提升指标中表现出最高的平均值和变化,这表明了独特的协作特征.
结论:
- 协会规则挖掘在识别临床试验现场合作方面是有效的.
- 第1阶段的试验合作比后期阶段更加专属.
- 在不同临床试验领域,协作特征在很大程度上有所不同.
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