探索暴露于挥发性有机化学物质和不孕症发生率之间的联系:一个横截面研究
Wen Zhang1,2, Jiarong He1, Fang Zhao3
1Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
Heliyon
|January 13, 2025
概括
诸如挥发性有机化合物 (VOC) 等环境污染物与女性不孕症有关. 较高水平的特定VOC,N-乙-S-(N-甲基卡巴莫伊尔) -L-氨酸 (AMCC) 和2-乙烯甲酸 (CYMA),显著增加不孕症的风险.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 越来越多的证据将环境污染物与对女性生育能力的不利影响联系在一起.
- 挥发性有机化合物 (VOC) 是空气中常见的污染物,可疑会对生殖产生影响.
- 关于VOC与不孕不育之间的关联,仍然缺乏明确的共识.
研究的目的:
- 调查暴露于挥发性有机化合物 (VOC) 和不孕症的患病率之间的关系.
- 用先进的统计模型分析特定的VOC及其与女性不孕症的关联.
主要方法:
- 使用NHANES数据 (2013-2018) 的横截面研究.
- 通过生殖健康问卷定义的不孕症.
- 使用了后勤回归,加权量子总和 (WQS) 和贝叶斯内核机器回归 (BKMR).
主要成果:
- 分析了1098名参与者 (120名不育,978名控制).
- 在不孕症组中观察到所有15种测量VOC的尿度升高.
- 最高四分位数的N-乙-S-(N-甲基碳酸) -L-氨酸 (AMCC) 和2-乙烯酸 (CYMA) 与不孕症的增加显著相关 (分别为OR=2.91和OR=2.28).
结论:
- 暴露于特定的VOC,特别是AMCC和CYMA,与女性不孕症相关.
- 炎症被认为是AMCC暴露和不孕症之间的关键调解因素.
- 这些发现有助于了解VOCs对生殖健康的影响.
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