周围血液NMLR可以预测慢性阻塞性肺部疾病患者的5年全因死亡率
Yuer Li1, Shaobo Ge1, Jin Liu1
1Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
International journal of chronic obstructive pulmonary disease
|January 13, 2025
概括
中性粒细胞与淋巴细胞的比率 (NMLR) 可以预测COPD患者的死亡率. 住院时较高的NMLR水平表明,慢性阻塞性肺病患者的5年全因死亡风险更高.
科学领域:
- 肺部医学 肺部医学
- 炎症性疾病 炎症性疾病
- 预测生物标志物 预测生物标志物
背景情况:
- 慢性阻塞性肺病 (COPD) 涉及全身和肺炎.
- 周围血液中性粒细胞+单细胞/淋巴细胞比率 (NMLR) 是各种炎症状况的已知预测指标.
- 在COPD患者中NMLR的预后意义以前未确定.
研究的目的:
- 研究外周血液NMLR在预测COPD患者5年全因死亡率中的预后价值.
- 为了确定NMLR和COPD恶化的死亡风险之间的关系.
主要方法:
- 对870名患有COPD恶化的患者进行了回顾性分析.
- 卡普兰 - 梅尔方法比较基于NMLR的死亡率.
- 多变量COX回归和受限制的立方支线模型,以评估NMLR对5年全因死亡率的独立预测值.
主要成果:
- 与幸存者相比,非幸存者表现出明显更高的NMLR值 (P=0.000).
- 在5年死亡率 (AUC=0.63) 中,NMLR的预测准确度中等.
- 升高的入院NMLR (≥5.90) 与5年全因死亡率 (27.3%对12.4%,P=0.000) 的显著增加有关,并被确定为独立预测因子 (HR=1.84,P=0.001). 在NMLR和死亡风险之间观察到非线性关系.
结论:
- 输入外周血液的NMLR是COPD患者5年全因死亡率的重要独立预测因子.
- 高的NMLR值表明临床预后较差,COPD死亡风险增加.
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