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免疫炎症指标与骨关节炎之间的关联 - NHANES 1999-2018年

Yan Xue^1,2, Cheng Chang^3,2, Yajun Chen^1,4

¹Department of Pediatrics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China.

Osteoarthritis and cartilage open

|January 13, 2025

概括

系统性免疫炎症指数 (SII) 在超过595.86.6时可能表明骨关节炎 (OA) 风险. 系统性免疫反应指数 (SIRI) 也显示了与OA患病率的正相关性,表明它们作为OA研究的生物标志物的潜力.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
公共卫生公共卫生

背景情况:

骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
人们越来越认识到系统性炎症在OA发病过程中的作用.
像SII和SIRI这样的新型炎症指数要求调查它们与OA的关联.

研究的目的:

研究系统性免疫-炎症指数 (SII) 和系统性免疫反应指数 (SIRI) 与骨关节炎 (OA) 之间的关联.
利用一个大型,全国代表性的数据集 (NHANES) 进行可靠的分析.
探索这些指数与OA之间的潜在值和剂量反应关系.

主要方法:

对1999-2018年NHANES数据的分析,包括人口统计,检查和实验室数据.
计算SII (血小板数 × 中性粒细胞数/淋巴细胞数) 和SIRI (中性粒细胞数 × 单细胞数/淋巴细胞数).
应用多变量逻辑回归和受限立方线回归 (RCS) 来评估SII,SIRI和OA之间的关系,并进行子组分析.

主要成果:

分析了32144名参与者 (12.16%患有OA) 的研究人口.
在未调整和部分调整模型中,在最高SII四分位数和OA之间观察到显著的正相关性.
确定了SII的临界值约为595.86,超过这个值后,OA的患病率显著增加. 在所有模型中,SIRI显示了与OA的一致的正相关性.

结论:

较高的SII水平,特别是超过595.86,可能与OA患病率的增加有关.
SIRI显示了与OA的显著正相关性,表明它有可能成为这种疾病的炎症标记物.
在未来的OA研究中,SII和SIRI可能作为有价值的生物标志物,值得进一步研究.

关键词:

尼汉斯 (NHANES) 是一个名人.骨关节炎是一种骨关节炎.在RCS中使用RCS.系统性免疫反应指数系统性免疫炎症指数在S-SII中.

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