儿童和提供者对每周一次的利法丁和异化结核病预防治疗的看法
A J Marthinus1, D T Wademan1, Z Saule1
1Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
IJTLD open
|January 13, 2025
概括
与六个月的异化 (6H) 疗法相比,12周每周一次的利法丁和异化 (3HP) 疗法减轻了儿童和护理人员的治疗负担. 然而,3HP的最佳整合需要教育和坚持支持才能成功完成.
科学领域:
- 公共卫生 公共卫生
- 儿童传染病 儿童传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 结核病 (TB) 预防性治疗 (TPT) 对于预防高危人群的疾病进展至关重要.
- 在高负担的环境中,对儿童的TPT的实施是不理想的,与标准的6个月异化 (6H) 治疗方案的持续时间和药片负担相关的挑战.
- 一个12周每周一次的Rifapentine和Isoniazid (3HP) 方案在一个可分散的药片配方被评估用于南非的儿科使用.
研究的目的:
- 探索儿童,护理人员和医疗保健提供者对儿童TPT3HP治疗方案的经验.
- 确定在高负担环境中实施3HP方案的潜在障碍和促进因素.
主要方法:
- 这是一项定性研究,涉及对20名儿童护理人员和9名医疗保健提供者的连续深入访谈.
- 参与者包括艾滋病毒感染儿童 (CLWH).
- 在两个参与3HP药理动力学和安全性试验的研究地点进行了采访,并以推断方式分析.
主要成果:
- 护理人员和医疗保健提供者更喜欢3HP疗法而不是6H疗法,因为它改善了口感和易于制备/施用.
- 人们对将每周一次的3HP剂量纳入常规临床实践表示担忧.
- 艾滋病毒感染儿童表示更喜欢每日6H疗法,因为它更容易与每日抗逆转录病毒治疗相结合.
结论:
- 3HP疗法显著降低了儿童及其照顾者的治疗管理负担.
- 成功完成每周一次的3HP方案需要有针对性的教育和坚持支持策略.
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