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Xiangbin Sun¹, Zhanpeng Xie¹, Zhen Wu¹

¹Medical School of Shihezi University, Shihezi, China.

Frontiers in immunology

|January 13, 2025

概括

接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者 (PWH) 可能会出现免疫不反应 (INR). 稳定肠道微生物群可以改善免疫功能和艾滋病毒/艾滋病的治疗结果.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
传染性疾病传染性疾病

背景情况:

艾滋病毒越来越多地被用抗逆转录病毒治疗 (ART) 作为慢性疾病来治疗.
一部分艾滋病毒感染者 (PWH) 尽管有ART,但仍表现出免疫不响应 (INR),导致二次感染和降低生活质量.
肠道微生物群的破坏与HIV/AIDS病原体内的免疫激活和炎症有关.

研究的目的:

定义和阐明艾滋病毒感染者 (PWH) 免疫不反应 (INR) 的机制.
探索肠道微生物群在INRs的发展和进展中的作用.
确定针对肠道微生物群的潜在治疗策略,以管理INR和改善艾滋病毒/艾滋病的免疫复原.

主要方法:

关于艾滋病毒,ART,INR和肠道微生物群的综合文献综述.
分析有关肠道失调和艾滋病毒免疫系统功能障碍之间的相互作用现有研究.
综合发现,提出以微生物为中心的方法来管理INRs.

主要成果:

在艾滋病毒/艾滋病的管理中,INRs代表了一个重大的临床挑战.
肠道微生物群的改变是持续免疫激活和炎症的关键因素.
有证据表明,肠道健康和ART在实现免疫复原方面的有效性之间存在联系.

结论:

针对肠道微生物群提供了一个有希望的治疗途径,用于解决PWH中的INR.
稳定肠道微生物群可能会减少免疫激活和炎症,从而改善免疫复原.
对微生物群调节的进一步研究可以提高艾滋病毒/艾滋病患者的长期结果.

关键词:

艺术艺术艺术艺术艾滋病毒/艾滋病病毒/艾滋病病毒在INRs中,INRs是指INR.我们的肠道微生物群.传统中国医学 (TCM) 是一种

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