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为增强乳腺癌免疫疗法提供BMS-1166的向交付

Zhecheng Yu^1,2,3,4, Zeya Zhou^1,2,3,4, Yunqi Zhao^1,2,3,4

¹College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, Zhejiang, People's Republic of China.

International journal of nanomedicine

|January 13, 2025

概括

这项研究开发了向纳米颗粒 (BMS-T7) 以提供PD-L1抑制剂 (BMS-1166) 用于乳腺癌免疫治疗. 向的细胞增强了药物递送和T细胞功能,显示了治疗TfR1阳性乳腺癌的前景.

科学领域:

纳米技术纳米技术
癌症免疫疗法癌症免疫疗法
药物运输药物运输药物运输

背景情况:

乳腺癌治疗在免疫疗法方面取得了进展,特别是针对编程死亡-1 (PD-1) /编程死亡-连接体1 (PD-L1) 途径.
BMS-1166是一种PD-L1抑制剂,转移素受体1 (TfR1) 在乳腺癌中过度表达,与T7相互作用.

研究的目的:

假设BMS-1166装载的T7修饰聚合基 (BMS-T7) 可以向TfR1阳性乳腺癌细胞.
评估BMS-T7作为一种向免疫疗法,以阻止PD-1/PD-L1相互作用.

主要方法:

将BMS-1166封装成T7-PEG-PCL小粒.
细菌性质的表征 (大小,形态,药物加载,释放).
在乳腺癌模型中评估细胞毒性,PD-L1抑制和T细胞激活.

主要成果:

在BMS-T7微粒中,呈现出最佳颗粒大小 (约. 60纳米) 和高封装效率 (83.89%).
与免费药物相比,BMS-T7在癌细胞和外体细胞上表现出更好的PD-L1抑制.
该配方显著恢复了T细胞功能,超过单独的BMS-1166治疗.

结论:

BMS-T7菌根显示了通过TfR1.1.向乳腺癌细胞提供向药物的潜力.
这种有针对性的方法有望增强癌症免疫治疗药物递送应用.

关键词:

在BMS-1166中使用.在PD-L1中.乳腺癌乳腺癌乳腺癌免疫疗法免疫疗法迈塞尔斯 (Micelles) 是一个很好的球员.

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