下血清IL-10与糖尿病患者的口腔表现有关
Nanan Nur'aeny1, Ahmedz Widiasta2, Yessy Novianti3
1Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Diabetes, metabolic syndrome and obesity : targets and therapy
|January 13, 2025
概括
这项研究发现,患有口腔问题的糖尿病患者具有较低的IN-10 (IL-10) 水平. 监测IL-10可能有助于确定患有口腔并发症风险的糖尿病患者.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 口腔医学是指口腔医学.
背景情况:
- 糖尿病是一种日益严重的全球健康问题,特别是在印度尼西亚.
- 在DM患者中,由于免疫系统的改变,口腔表现很常见.
- 介质素-10 (IL-10) 是一种与DM相关的炎症标志物,但其在口腔并发症中的作用尚未得到研究.
研究的目的:
- 为了比较非DM患者的血清IL-10水平与有或没有口服表现的DM患者.
- 调查IL-10水平与糖尿病口腔并发症之间的关联.
主要方法:
- 具有横截面设计的观察性研究.
- 包括88个血清样本:37个非DM,35个DM有口腔表现,16个DM没有口腔表现.
- 使用ELISA套件测量血清IL-10水平.
主要成果:
- 在DM患者中, Xerostomia是最常见的口腔表现 (80%).
- 平均血清IL-10水平为0.93 pg/mL (非DM),0.80 pg/mL (口腔表现的DM) 和1.08 pg/mL (没有口腔表现的DM).
- 在两组中观察到IL-10水平的显著差异 (p=0.008).
结论:
- 与没有口腔问题的非DM和DM患者相比,患有口腔表现的DM患者的血清IL-10水平较低.
- IL-10水平可以作为生物标志物来识别易患口腔并发症的糖尿病患者.
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