血清与的比率和在连续的门诊腹膜透析中的死亡率:一个多中心的回顾性研究
Jiayin You1, Sijie Gu1, Ning Su2
1Department of Nephrology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
MedComm
|January 13, 2025
概括
腹腔透析 (PD) 患者血清与比 (Na/Cl) 水平较高,与死亡率降低有关. 这一发现表明Na/Cl可能是PD患者有用的预后标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
背景情况:
- 血清与比 (Na/Cl) 不平衡与心力衰竭的死亡率增加有关.
- 在腹腔透析 (PD) 患者中Na/Cl的预后价值尚不清楚.
研究的目的:
- 为了研究基线Na/Cl水平和PD患者的死亡率之间的关联.
- 为了确定Na/Cl是否可以作为PD患者的预后指标.
主要方法:
- 一项多中心研究包括2005年至2021年3341名PD患者.
- 根据基线的Na/Cl.患者被分为四分位数.
- 使用了考克斯的比例危险模型,竞争风险模型和受限制的立方线分析.
主要成果:
- 在最高Na/Cl四分位数 (>1.42) 的患者,与最低四分位数 (<1.33) 相比,所有原因死亡率 (HR 0.63) 和心血管死亡率 (HR 0.38) 显著降低.
- 一个连续变量分析证实了Na/Cl水平与死亡率之间的负相关性.
- 针对并发症和其他共变量进行了调整.
结论:
- 初始血清Na/Cl水平与PD患者的全因和心血管死亡率相反相关.
- 较高的基线Na/Cl可能表明PD患者的预后更好.
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