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与NAFLD相关的SNP对动脉样硬化发展的影响;为期五年的前性观察性研究

Hiroaki Ikezaki^1,2,3, Ryoko Nakashima¹, Yuji Matsumoto¹

¹Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.

Atherosclerosis plus

|January 13, 2025

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了心血管风险. 与MASLD相关的某些基因变异 (SNP) 可能会影响日本人的动脉样硬化发展,特别是影响脂质谱.

科学领域:

心血管健康心血管健康
遗传学遗传学是一个
肝病学肝病学是一种肝病学.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为非酒精性脂肪性肝病 (NAFLD),是与增加动脉样硬化心血管疾病风险相关的日益严重的公共卫生问题.
了解MASLD的遗传基础对于预测和减轻相关心血管并发症至关重要.

研究的目的:

研究与MASLD相关的特定单核酸多态 (SNPs) 对动脉样硬化发展的影响.
为了检查这些协会在日本人口队列特别选择的缺乏糖尿病,脂质失调和高血压.

主要方法:

一项前性观察性研究,涉及九州和冲绳人口研究 (KOPS) 的945名参与者.
在5年内通过超声波测定与MASLD相关的SNP (GCKR,NCAN,PNPLA3) 的基因型,并通过超声波测量动脉内膜介质厚度 (cIMT).
使用单变量和多变量回归的统计分析,以确定SNP与新发性动脉动脉样硬化的关联.

主要成果:

在NCAN (rs2228603) T等位基因与心血管动脉样硬化发病率降低 (p=0.04) 之间发现了显著的关联.
携带NCAN T等位基因的携带者表现出更有利的脂质特征.
虽然GCKR和PNPLA3等位基因表现出较低动脉样硬化率的趋势,但这些发现在统计学上并不显著.

结论:

某些与MASLD相关的SNP,特别是NCAN基因中的SNP,可能在调节动脉样硬化发展方面发挥作用.
这些对动脉样硬化的遗传影响似乎在没有代谢综合征特征的日本个体中通过脂质代谢途径运作.

关键词:

动脉样硬化是一种动脉样硬化.冠状动脉内膜介质的厚度这是NAFLD.在NCAN和NCAN之间.在SNP中,SNP是SNP.

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