克莱马斯烟酸通过增强热致死,加速在渐进的多发性硬化症中残疾的积累

Joanna Kocot1, Peter Kosa1, Shinji Ashida1

  • 1Neuroimmunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA.

概括

克莱马斯烟酸,在多发性硬化症 (MS) 复髓化方面进行了探索,通过激活细胞死亡途径 - - 活化灭亡 (pyroptosis) 来意外造成伤害. 这条涉及P2RX7的途径与MS进展和中枢神经系统损伤有关.

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