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Updated: Jun 3, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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TERT剪接的遗传调节通过改变细胞寿命和复制潜力,有助于降低或增加癌症风险

Oscar Florez-Vargas1, Michelle Ho1, Maxwell Hogshead1

  • 1Laboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.

medRxiv : the preprint server for health sciences
|January 13, 2025
PubMed
概括

在TERT内部6 (VNTR6-1) 中一个可变数串重复和内部4中的GWAS信号通过改变端粒酶 (TERT) 表达和拼接来影响癌症风险,从而影响细胞寿命.

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