Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

295
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
295
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

165
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
165
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

499
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
499
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

997
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
997
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

526
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
526
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

141
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
141

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Bone and Radiologic Findings in Congenital Generalized Lipodystrophy: A Systematic Review and Report of 60 Cases.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Type B insulin resistance with glycemic extremes: a case report and literature review.

Frontiers in endocrinology·2026
Same author

Case Report: Twenty years of metreleptin therapy in congenital generalized lipodystrophy type 1: the longest reported follow-up to date.

Frontiers in endocrinology·2026
Same author

Classical homeostatic physiology sheds light on vitamin D controversies.

Trends in endocrinology and metabolism: TEM·2026
Same author

Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses.

Clinical and translational science·2026
Same author

Genotype-first approach reveals monogenic lipodystrophy is underdiagnosed, with health and mortality risks.

EBioMedicine·2026

相关实验视频

Updated: Jun 3, 2025

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
08:44

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Published on: July 30, 2020

4.2K

蒂尔泽帕提德用于治疗脂质疏松症.

Rasimcan Meral, Merve Celik Guler, Diarratou Kaba

    medRxiv : the preprint server for health sciences
    |January 13, 2025
    PubMed
    概括

    蒂尔泽帕提德在治疗罕见的代谢障碍脂质变症方面表现有前途. 这种双重的隐素药物显著改善了部分或泛性脂质变质症患者的BMI,HbA1c和甘油三水平.

    更多相关视频

    Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
    08:30

    Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

    Published on: June 2, 2015

    9.3K
    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
    07:59

    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

    Published on: July 21, 2017

    9.6K

    相关实验视频

    Last Updated: Jun 3, 2025

    Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
    08:44

    Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

    Published on: July 30, 2020

    4.2K
    Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
    08:30

    Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

    Published on: June 2, 2015

    9.3K
    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
    07:59

    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

    Published on: July 21, 2017

    9.6K

    科学领域:

    • 内分泌学和新陈代谢学
    • 罕见的遗传疾病 罕见的遗传疾病
    • 药理干预药理干预

    背景情况:

    • 脂质疏松症是一组罕见的疾病,其特点是脂肪分布异常和严重的代谢并发症.
    • 在脂质缩中脂肪细胞质量减少导致异胎脂存储和代谢功能障碍.
    • 之前的研究表明,在家族局部脂质缩症 (FPLD) 中,类似葡萄糖素的-1激动剂有好处.

    研究的目的:

    • 为了研究双重基素的提尔泽帕提德的疗效,作为诊断为脂质营养不良的患者的潜在治疗方法.
    • 评估蒂尔泽帕提德对部分脂质变 (PL) 或泛性脂质变 (GL) 个体的代谢参数的影响.

    主要方法:

    • 一项观察性队列研究跟踪了PL或GL患者,这些患者在临床上接受了提尔泽帕提德治疗.
    • 数据是在正在进行的脂质营养不良的自然历史研究的框架内收集的.
    • 17名患者 (14名患有FPLD,3名患有获得的GL) 接受了蒂尔泽帕提德,随着时间的推移对代谢标志物进行了监测.

    主要成果:

    • 在FPLD患者中,提尔泽帕提德治疗导致BMI,HbA1c,甘油三水平和每日胰岛素需求显著降低.
    • 获得性泛性脂质变 (GL) 患者的BMI,HbA1c,甘油三和胰岛素需求也显著改善.
    • 三名患者经历了剂量限制的胃食道逆流,阻碍了进一步的剂量升级.

    结论:

    • 提尔泽帕提德显示出作为有效治疗剂的潜力,用于管理脂质营养不良患者的代谢障碍.
    • 这些发现支持进一步调查提尔泽帕提德用于治疗脂质疏松症,尽管存在一些耐受性问题.