在ENIGMA自杀思想和行为联盟中,与自杀思想和行为相关的白质微观结构的跨诊断性改变
Laura S van Velzen1,2, Lejla Colic3,4,5, Zuriel Ceja6,7
1Orygen, Parkville, VIC, Australia.
medRxiv : the preprint server for health sciences
|January 13, 2025
概括
白物质 (WM) 微观结构的改变与自杀企图的历史有微妙的联系,特别是在特定的大脑区域. 然而,最近的自杀想法与这些WM变化没有任何关联.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 白质 (WM) 微观结构的改变被假设与自杀思想和行为 (STBs) 有关.
- 之前的扩散张力成像 (DTI) 研究在性病中调查WM的研究已经产生了不一致的结果.
- 需要进行大规模的超级分析来澄清WM微观结构和STB之间的关系.
研究的目的:
- 用大规模的超级分析来调查与自杀思想和行为 (STBs) 相关的白质 (WM) 微观结构变化.
- 为了比较WM微观结构的措施,与自杀尝试的历史,临床对照和健康对照的个人之间.
- 与对照组相比,检查最近有自杀念头的个体的WM微观结构.
主要方法:
- 这是一项从40个队伍的扩散张力成像 (DTI) 数据的大型分析,在各个站点进行了标准化.
- 对25个WM区域进行了WM微结构测量 (分数异构,扩散性) 的分析.
- 组之间进行了比较:自杀尝试史,精神病控制,健康控制和最近的自杀念头组.
主要成果:
- 微妙但从统计学上显著的分数异构性减少与自杀未遂史有关,独立于精神病学诊断.
- 这些WM变化在冠状辐射,乳头辐射,/丝末端,体和上纵侧囊中最为明显.
- 最近的自杀念头和WM微观结构变化之间没有发现任何显著的关联.
结论:
- 这项大规模的研究确定了WM微观结构中微妙的区域和全球变化,这些变化发生在那些有过自杀企图的个人身上.
- 观察到的WM变化在效果大小上很小,这表明它们可能代表一个微妙的生物标志物.
- 建议进行长度研究,以确定这些WM变化是否是未来自杀行为的风险因素.
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