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多原子生物标志物在不协调的单胞胎双胞胎中区分类风湿性关节炎

Rebecca B Blank¹, Kevin Bu², Weixi Chen³

¹Division of Rheumatology, NYU School of Medicine.

medRxiv : the preprint server for health sciences

|January 13, 2025

概括

患有类风湿性关节炎 (RA) 的同卵双胞胎显示肠道细菌Blautia faecis和有益的短链脂肪酸水平降低. 这些多omics生物标志物可能有助于了解RA的发展,并为新疗法提供信息.

科学领域:

免疫学免疫学免疫学
微生物组研究的研究.
遗传学是一个遗传学.

背景情况:

风湿性关节炎 (RA) 的发病包括遗传因素,但同卵双胞胎的低一致性表明非遗传影响.
在基因相同的个体中导致RA的特定非遗传因素的特征仍然很差.

研究的目的:

在单胞胎 (MZ) 双胞胎中识别不同的宿主和微生物生物标志物,这些生物标志物对类风湿性关节炎 (RA) 不一致.
通过使用MZ双胞胎的多omics方法,研究非遗传因素在RA发展中的作用.

主要方法:

研究了八对MZ双胞胎对RA不一致.
通过中枪元基因组测序评估肠道微生物组.
使用GC-MS测量血清和便中的自身抗体,细胞因子,血蛋白和短链脂肪酸 (SCFA).

主要成果:

双胞胎之间在整体微生物群多样性或组成上没有显著差异.
在RA受影响的双胞胎中观察到的Blautia faecis水平降低.
在受影响的双胞胎中发现自抗体升高和便丁酸盐和酸盐 (SCFA) 降低.

结论:

多omics分析揭示了不同的生物标志物,区分了RA和没有RA的MZ双胞胎.
在RA双胞胎中减少的Blautia faecis和SCFA表明肠道屏障炎症相互作用.
这些发现可以提高对RA病变的理解,并为新的诊断和治疗策略提供信息.

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