患者报告的营养状况,毒性和有限阶段SCLC的存活率之间的关联
Evgenia Taranova1,2, Marianne Aanerud1,2, Tarje O Halvorsen3,4
1Department of Clinical Science, University of Bergen, Bergen, Norway.
JTO clinical and research reports
|January 13, 2025
概括
营养状况和体重减轻没有显著影响治疗毒性或在接受化疗或放射治疗的有限阶段小细胞肺癌 (LS-SCLC) 患者的存活率. 这项研究发现,营养不良风险与患者的结果之间没有相关性.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 辐射疗法 辐射疗法
背景情况:
- 营养不良通常与癌症治疗毒性增加和生存率降低有关.
- 它对有限阶段小细胞肺癌 (LS-SCLC) 的具体影响仍未得到充分研究.
研究的目的:
- 评估营养状况和体重减轻与LS-SCLC患者治疗结果之间的关联.
- 分析与营养不良风险相关的毒性,无进展生存率 (PFS) 和总生存率 (OS).
主要方法:
- 一个随机试验 (NCT02041845) 涉及170名LS-SCLC患者接受乙化疗和胸部放射治疗 (TRT).
- 用患者生成的主观全球评估简单表格 (PG-SGA SF) 评估营养状况,将患者分类为低,中等和高营养不良风险.
- 还记录了体重减轻 (≥5%在3个月内).
主要成果:
- 在113名分析患者中,在营养不良风险类别中,在3-4级毒性,中位数PFS或中位数OS中没有发现显著差异.
- 报名前的体重减轻 (≥5%) 也没有与毒性,PFS或OS显著相关.
结论:
- 患者报告的营养状况和治疗前的体重减轻与该LS-SCLC队列的治疗毒性或生存结果没有显著联系.
- 这些发现表明,营养状况可能不是这个特定的患者群体和治疗方式的关键预后因素.
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