数据描述了一组可生物降解的交联聚植入物的面板,用于持续输送抗病毒药物
Sungmin Jung1, Jack Bufton1, Zeqing Bao1
1Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada.
Data in brief
|January 13, 2025
概括
新的可交叉链接的聚共聚合物提供了一个有前途的长期作用的传递系统为tenofovir alafenamide (TAF). 这些可植入磁盘可以改善慢性乙型肝炎病毒和人类免疫缺陷病毒感染的药物输送.
科学领域:
- 聚合物化学 聚合物化学
- 药物输送系统是药物输送系统.
- 生物材料科学是生物材料的科学.
背景情况:
- 诺福维尔阿拉芬胺 (TAF) 是一种治疗慢性乙型肝炎病毒 (HBV) 和人类免疫缺陷病毒 (HIV) 感染的口服药物.
- 长效的TAF配方可以提高患者的坚持性,方便性和药物有效性,同时最大限度地减少副作用.
- 目前以聚合物为基础的输送系统主要使用聚酸乳酸-合糖化物 (PLGA).
研究的目的:
- 探索用于TAF输送的新型可交叉链接的基功能化聚共聚合物.
- 开发和描述盘状,可植入的TAF输送系统.
- 评估这些新聚合物的潜力,作为TAF的持续释放平台.
主要方法:
- 合成和表征基功能化聚共聚合物.
- 制造盘状植入物. 盘状植入物的制造.
- 评估植入物物理化学性质 (热,光谱,体外稳定性).
- 通过胀平衡和体外药物释放研究来测试TAF负载.
主要成果:
- 成功准备和表征了新的聚共聚合物.
- 开发出具有经过评估的物理化学性质和体外稳定性的可植入磁盘.
- 实现了TAF加载,并证明了在体外从聚合物盘中控制的药物释放.
结论:
- 基功能化聚共聚合物显示出作为TAF长效植入物的可行材料的潜力.
- 这些新材料为持续药物输送应用提供了PLGA的替代品.
- 开发的系统显示了改善TAF在HBV和HIV治疗中的承诺.
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