原发性硬化胆管炎和微观结肠炎之间的关联:系统性审查
Hasan Al-Obaidi1, Mustafa Al-Obaidi2, Pratiksha Moliya3
1Internal Medicine, Jamaica Hospital Medical Center, New York, USA.
Cureus
|January 13, 2025
概括
原发性硬化性胆道炎 (PSC) 和微观性结肠炎 (MC) 具有共同的联系,MC通常在PSC后被诊断出来. 在PSC患者中提高对MC的警对于早期检测和管理至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 有限的研究表明,原发性硬化性胆道炎 (PSC) 和显微性结肠炎 (MC) 之间存在联系.
- 潜在的共享病理生理机制需要进一步研究.
- 了解这种关联对于患者管理至关重要.
研究的目的:
- 系统地审查和分析有关PSC和MC之间关联的现有文献.
- 确定共同的风险因素和临床影响.
- 为临床实践和未来研究方向提供信息.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了全面的文献搜索.
- 包括两个研究:一个病例系列 (12名患者) 和一个病例报告 (1名患者).
- 对诊断时间,临床表现和建议机制的分析.
主要成果:
- 显微性结肠炎的诊断发生在原发性硬化性结肠炎后,在病例系列中的75%的病例中.
- 许多微观结肠炎病例无症状,这表明潜在的诊断不足.
- 共同的机制包括免疫失调,遗传倾向 (例如,HLA-DR3) 和肠道微生物群的改变.
结论:
- 初级硬化性胆道炎和显微性结肠炎之间存在显著的关联.
- 建议增加对PSC患者微观结肠炎的临床警.
- 需要进一步的研究来验证发现,并探索查和治疗策略.
相关概念视频
Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Inflammatory Bowel Disease I: Ulcerative Colitis
134
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
134
Chronic Pancreatitis I: Introduction
71
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
71
Inflammatory Bowel Disease II: Crohn's Disease
183
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
183
Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K


