在埃及的马类类动物中,牛 三角形乳头瘤病毒 的分子表征
Nader Maher Sobhy1,2, Walid Refaai3, Rahul Kumar4
1Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Sharkia 44511, Egypt.
Veterinary medicine international
|January 13, 2025
概括
牛乳头瘤病毒1型 (BPV1) 是埃及马类肉的主要病因. 遗传分析显示,在马,驴和牛中发现的BPV1中,遗传学变异很小.
科学领域:
- 兽医病毒学 兽医病毒学
- 马类皮肤病学 马类皮肤病学
- 分子流行病学分子流行病学
背景情况:
- 马类瘤 (ESs) 是一种影响全球马和驴的皮肤瘤.
- 这些由牛乳头瘤病毒 (BPV) 引起的瘤会影响动物的福利和工作能力.
- 马匹的BPV感染带来了重大的经济和化品挑战.
研究的目的:
- 为了确定在埃及导致马类肉病的特定BPV类型.
- 调查BPV从马匹中分离的遗传多样性和遗传学关系.
- 了解马和驴的BPV感染的分子基础.
主要方法:
- 在扎加齐格大学兽医诊所从被诊断出患有沙虫的马匹和驴取样本.
- 病毒DNA提取和测序L1基因和其他病毒基因.
- 遗传学分析和比较BPV序列与参考菌株.
主要成果:
- 牛乳头瘤病毒1型 (BPV1) 被确定为所有测试的马类肉病例中的致病原体.
- 从马和驴中测序的BPV1分离体显示出与参考BPV1菌株的高遗传同一性 (98.5%).
- 遗传学分析显示,BPV1有两个不同的基因组,而马类和牛类分离物之间没有具体的区别.
- 与其他病毒基因相比,在E5和L2基因中观察到显著的遗传变异.
结论:
- 在被研究的埃及人群中,BPV1是马类肉的主要原因.
- 在该地区感染牛,马和驴的BPV1之间存在有限的基因变异.
- BPV1的遗传稳定性表明,它在马类肉类的发育中发挥着一致的病因作用.
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