对创伤相关的精神病理与生殖衰老之间的双向关系进行系统审查
Amanda R Arnold1, Trinidi Prochaska1, Maximilian Fickenwirth1
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Journal of mood and anxiety disorders
|January 13, 2025
概括
生殖衰老加剧了创伤暴露的女性的抑郁和创伤后应激障碍 (PTSD) 症状. 需要更多的研究来了解影响这些行为健康结果的神经内分泌变化.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 妇女健康 妇女健康
背景情况:
- 卵巢类固醇激素在女性寿命的波动与抑郁症和创伤后应激障碍 (PTSD) 症状的风险增加有关.
- 生殖衰老对受创性妇女大脑和行为健康的影响还未得到充分研究.
- 创伤心理病理与生殖衰老之间的双向关系需要进一步研究.
研究的目的:
- 系统地审查有关创伤史,精神病理和更年期在生殖衰老期间的相互作用的文献.
- 在经历创伤的妇女中识别脆弱时期和症状模式,这些妇女正在经历生殖衰老.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 在PubMed,PsychInfo和Medline数据库中对受控研究进行了搜索.
- 资格标准侧重于创伤史,心理病理学和生殖衰老期间更年期症状.
主要成果:
- 21项研究符合纳入标准;只有4项使用STRAW+10进行生殖衰老分期.
- 绝经前期和绝经后期的阶段对于遭受创伤的人来说特别脆弱.
- 更年期症状和与创伤相关的精神病理严重程度随着生殖衰老和创伤暴露程度的增加.
结论:
- 关于生殖衰老和神经内分泌变化如何影响与创伤暴露女性PTSD和抑郁症相关的大脑功能存在重大知识差距.
- 这种缺乏理解,阻碍了这些疾病的有效识别,评估和治疗.
- 解决这个差距对于减轻老年妇女的长期健康后果,包括发病率和死亡率至关重要.
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