在氧化视网膜病变中的光学连贯性断层扫描特征以及与台湾人视力恶化的相关性
Shao-Kai He1, Tso-Ting Lai2,3, Yi-Ting Hsieh2,3
1National Taiwan University Hospital, Taipei, Taiwan.
Taiwan journal of ophthalmology
|January 13, 2025
概括
台湾患者的氧化 (HCQ) 视网膜病变主要表现为心周病变. 视网膜色素上皮质 (RPE) 的破坏,而不是圆形区域 (EZ) 的变化,显著影响视力敏度的丧失.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜成像 视网膜成像
- 药理学毒性 药理学毒性
背景情况:
- 氧化 (HCQ) 广泛用于自身免疫性疾病.
- 长期使用HCQ可能导致视网膜病变,可能导致不可逆转的视力丧失.
- 早期检测和了解HCQ视网膜病变模式对于患者管理至关重要.
研究的目的:
- 调查氧化 (HCQ) 视网膜病变中的光学连贯性断层扫描 (OCT) 发现.
- 在台湾患者中,将OCT特征与视力敏度相关联.
- 确定导致HCQ视网膜病变视力恶化的关键因素.
主要方法:
- 对长期接受HCQ治疗的患者的回顾性分析.
- 收集最佳校正的视敏度和OCT扫描数据.
- 利用主要组件分析 (PCA) 来确定影响视力下降的因素.
主要成果:
- 在35%的眼睛中检测到HCQ视网膜病变 (42/120).
- 轻度至中度病例主要表现为周围中心病变 (75%);没有单独的状表现.
- 在所有受影响的眼睛中都出现了圆形区域 (EZ) 干扰;在59.5%的病例中发现了视网膜色素表皮质 (RPE) 干扰.
- 经过PCA的检测,发现叶和叶RPE中断与视力恶化有很强的联系.
结论:
- 台湾患者的HCQ视网膜病变通常始于心周病变.
- 隔离的偏膜病变是不常见的初始表现.
- 尤其是视网膜中部区域的RPE中断,是比EZ中断更显著的视力敏度丧失的预测因素.
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